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Genome-scale CRISPR screening in a single mouse liver

Keys, H.R. and Knouse, K.A.

Cell Genomics. 2022 Dec 14;2


Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential

Swartz, S.Z., McKay, L.S., Su, K.C., Bury, L. Padegeh, A., Knouse, K.A., and Cheeseman, I.M.

Developmental Cell. 2019 Oct 7;51(1):35-48


Chromosome segregation fidelity in epithelia requires tissue architecture

Knouse, K.A., Lopez, K.E., Bachofner, M., and Amon, A.

Cell. 2018 Sep 20;175(1):200-211


In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease

Stevens, K.R., Scull, M.A., Ramanan, V., Fortin, C.L., Chaturvedi, R.R., Knouse, K.A., et al.

Science Translational Medicine. 2017 Jul 19;9(399)

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Santaguida, S., Richardson, A., Iyer, D.R., M’Saad, O., Zasadil, L., Knouse, K.A., et al.

Developmental Cell. 2017 Jun 19;41(6):638-651

Aneuploidy in Cancer: Seq-ing Answers to Old Questions

Knouse, K.A., Davoli, T., Elledge, S.J., and Amon, A.

Annual Review of Cancer Biology. 2017 Mar;1:335-354

Detection of Copy Number Alterations Using Single Cell Sequencing

Knouse, K.A., Wu, J., and Hendricks, A.

Journal of Visualized Experiments. 2017 Feb 17;(120)



Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

Pfau, S.J., Silberman, R.E., Knouse, K.A., and Amon, A.

Genes and Development. 2016 Jun 15;30(12):1395-408

Assessment of megabase-scale somatic copy number variation using single-cell sequencing

Knouse, K.A., Wu, J., and Amon, A.

Genome Research. 2016 Mar;26(3):376-84


Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

Knouse, K.A., Wu, J., Whittaker, C.A., and Amon, A.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13409-14

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